I've attached an e-Paper display to an Onion Omega via USB-to-TTL serial adapter, mounted it in a picture frame, and exposed it to the internet. The Omega's lighttpd is serving the website and running the CGI, proxied by my dedicated server via ssh tunnel.
See http://www.pictureframeofthings.com/ to play with it live. Yes, it's sitting on my desk, updateable by anyone. The photo below is the background image for the website, which overlays a preformatted text block to present what's actually on the screen right now.