I know this is an old thread but I just got HomeAssistant running on my Omega2+ and wanted to follow up. I did the following;

• I factory reset my Omega2+ to latest software/console
• I extended the storage to use the SD card (3GB)
• I added a 250MB swap file to extend the memory
• I installed python 3, pip3 and upgraded pip3 setuptools

I also didn't use virtualenv. HomeAssistant installed and ran without any special changes and I could view the UI at http://omega-xxxx.local:8123/. It did take a very long time (20 mins) to install and run though.