Hey @Sushanth-Varada -- The grpcio wheel includes a shared object library. There are downloads for AMD and ARM architectures but not MIPS (as used by the Omega). Someone could provide a build for the Omega but this hasn't been done perhaps because it may hit the device's resource constraints. An alternative -- if you're not bound to Python -- is to use one of the other languages (for which there are protobuf generators) that supports cross-compilation (and static binaries) including Golang and Rust. With Golang, you may develop on one platform and then cross-compile the code to run it on an Omega: GOOS=linux GOARCH=mipsle go build -o your-binary /path/to/main.go I used the Golang helloworld sample and the client produces a ~12MB binary that runs on the Omega.