I too would love a precompiled version of the serialport npm package delivered via opkg as I dont think npm node-gyp compilation is ever going to work. This is the way the Arduino Yun supports serial via nodejs (it also uses same chipset and similar openwrt distro). I noticed opkg has a node-usb package one but it doesnt seem to do anything. Cant find it on the file system, neither as npm global package or under /usr/bin directory, I also cant seem to use it via require('usb').